Endocrine Abstracts

IntroductionHypoparathyroidism (hypoPT) is one of the most complications after thyroid surgery, usually as transient hypocalcemia. Permanent hypoPT due to permanent parathyoid lesion, despite being less frequent, is associated to long term consequences for both objective and subjective well-being and should be prevented. Identifying predictive factors associated with post- thyroidectomy hypoPT is thereby crucial.Aim<p class="ab...

IntroductionCOVID-19 is an emerging disease caused by the new coronavirus (SARS-CoV-2) that has overburdened healthcare worldwide. In Portugal, schedule appointments were cancelled, postponed or changed to tele-consultation. The objective of the study is to assess the impact of the pandemic on the use of Emergency Department (ED) by diabetic patients.Material and methodsRetrospective monocentric study of the ...

Introduction: Medullary thyroid cancer (MTC) is a rare tumour. Mostly sporadic, 25% are associated with multiple endocrine neoplasia (MEN2A/B) or isolated familial MTC. Surgery is the only curative option: its response is defined as complete (no evidence of biochemical or structural disease), incomplete (only structural response) and persistence of structural disease. We aimed to analyse the clinical and pathological factors associated with the prognosis of MTC.<p class="a...

Introduction: Severe hypercalcemia is defined as a total serum calcium level >14 mg/dl or ionized calcium >10 mg/dl . The most common causes are primary hyperparathyroidism (PHPT) and neoplasms (90% of cases). Vitamin D intoxication is an extremely rare cause. Case Report: A 56-year-old man presented to the emergency department with vomiting, generalized weakness and complaints of imbalance over one week. Upon physical examination, he displayed c...

Introduction: Medullary thyroid carcinoma (MTC) arises from thyroid parafollicular C cells and accounts for <5% of thyroid cancers. Nearly 25% occur in the context of multiple endocrine neoplasia type 2 syndrome (MEN2) or familial isolated MTC.Objectives: Evaluation of clinical characteristics and evolution of patients with MTC.Methods: Retrospective analysis of clinical records of patients with MTC diagnosed from 2001 to 2023....

Introduction: Mitochondrial uncoupling proteins (UCPs) are channel proteins present in the mitochondrial inner membrane which are responsible for the transport of protons between the mitochondrial intermembrane space and the matrix. Currently, six UCP homologues had been identified (UCP1-6). UCPs are major regulators of reactive oxygen species (ROS) production, general cellular redox state and metabolism. UCPs also exhibit specific functions, such as UCP1 and thermogenesis or ...

Metabolic and endocrine dysregulation induced by high-fat diet (HFD) can lead to decreased male fertility potential and have a negative impact on the offspring’s metabolic health. Small non-coding RNAs (sncRNAs) were proposed as being potential mediators of metabolic queues across transgenerational inheritance. During development and epidydimal transit, spermatozoa become enriched with tRNA-derived stress-induced RNAs (tiRNAs). This sncRNAs class appears to be particularl...

Background: In 15% of prolactinomas there is dopamine agonist(DA) resistance. The clinical characteristics, the best diagnostic and therapeutic management of these cases have not been established so far.Aim: To characterize patients taking a high dose cabergoline(≥ 3mg/week) and then describe clinical, biochemical and imaging features of cabergoline-resistant cases.Methods: Retrospective study with 5 centers representing the ...

Introduction: Atrazine is one of the most widely used pesticides worldwide and a common contaminant in human drinking water. Atrazine is also a potent endocrine disruptor capable of causing a variety of negative health outcomes, including decreased testosterone production and infertility. Although harmful effects of atrazine on male reproductive health have been reported, little is known about its molecular mechanisms. Within the seminiferous tubules, Sertoli cells are respons...

This paper aims to describe the followed population in the consultation, through a retrospective study in a hospital unit. This retrospective study was carried out during February 2020 to February 2022, and analyses the clinical processes of the patients that were followed in this consultation, and later analysing the data using Microsoft Excel® Over these two years, 395 patients were observed. These patients age average 61 years old, ranging from 17 to 93 years of age. M...